Why are we seeing these changes in the human microbiota? Studies show that the western lifestyle promotes a suboptimal phenotype, in the sense that highly processed diets, sedentary living, lack of sun exposure, etc., results in a gene expression that leads to poor health and disease (1,2). However, we’re now learning that this gene-environment mismatch in many ways also involves the second genome in our bodies, in the sense that the western lifestyle is a
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[…] lack of sun exposure, etc., results in a gene expression that leads to poor health and disease (1,2). However, we’re now learning that this gene-environment mismatch in many ways also involves […]
[…] fiber every day (3, 4). Besides supplying bacteria with fermentable substrates, hunter-gatherers routinely pick up new microorganisms from dirty food, soil, and the rest of the natural […]
[…] – with its antibiotics, hand sanitizers, refined food, and caesarean sections – selects for a very different microbiota than the one our ancestors carried around. For millions of years we developed a close relationship with bacteria, archaea, and other […]
[…] and non-westernized people who lead a traditional lifestyle have revealed that these people carry a microbiota characterized by a much greater biodiversity than the microbiota of westerners. Overuse of antibiotics, consumption of highly processed diets, […]
[…] by much greater biodiversity when compared with a “Westernized microbiota”. Basically, there’s plenty of evidence to suggest that we’ve lost some microbial “old friends&… that co-evolved with our ancestors for millions of years. Not only that, but many of us have […]
[…] plenty of evidence to suggest that we’ve lost some old microbial friends that co-evolved with our ancestors for millions of years. This loss of biodiversity is an important underlying cause of many chronic diseases; in particular […]
[…] triggered or exacerbated by microbial imbalances in the gut have skyrocketed in prevalence lately (13, 14, […]