The microbiome and the brain are the chief regulators of adiposity and eating behavior in humans. In many respects, the microbiome is even more influential than the brain. While the many processes occurring in the brain ultimately shape our thoughts and behavior, they are in turn heavily influenced by signals issuing from other areas—like the gastrointestinal microbiome and adipose tissue.

Some experts even characterize the brain as a puppet controlled by the body’s

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