The Tsimane are an ancestral population who live in the rainforest of Bolivia. They source food from a combination of horticulture and foraging. They have a known high burden of infection and inflammation. Yet their risk of cardiovascular disease is among the lowest in the world.

Another nearby group, the Moseten, are genetically similar to the Tsimane. This group is more modernized than the Tsimane, but not to the degree of the United States.

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